In agreement with spectral flow analysis, CITE-Seq analysis uncovered that, at the single-cell level, the frequency of monocytic MDSCs (CD33+CD11b+HLA-DRlo/–CD14+CD15– cells) was drastically elevated in the microenvironment of AML with TP53 and TET2 comutations (Supplemental Figure 8, D–H). This evidence concerns the gene ITGAM and acute myeloid leukemia.