TP53 and acute myeloid leukemia: This comparative analysis revealed that Vav-cre Tet2fl/flTp53fl/fl murine AML cells significantly align transcriptionally with TP53/TET2 comutant human AML cells compared with single-mutant or WT control cells (binomial test, P < 2.2 × 10–16, predicted probability = 0.25, observed probability = 0.78, 95% confidential interval = 0.76) (Supplemental Figure 3, E and F).