In sharp contrast, stem cell gene, Cd34; lineage gene, Gata2; and leukemia stem cell regulator, Ikzf2; as well as Tnfaip3, Pvr (Cd155), and Nectin2 (Cd112), were upregulated in Vav-cre Tet2fl/flTp53fl/fl GMPs (Figure 7A). Here, TNFAIP3 is linked to leukemia.