Among T cell populations, a subset of Cd3e+Tigit+Pd1+Lag3+ T cells, indicative of exhaustion, was identified in samples from Vav-cre Tet2fl/flTp53fl/fl AML mice (Supplemental Figure 9, F and G, and Supplemental Figure 10, A and B). Here, LAG3 is linked to acute myeloid leukemia.