Splenocytes of Vav-cre Tet2fl/flTp53fl/fl mice that developed AML had substantially increased frequencies of Cd11b+Gr-1– and Cd11b+Gr-1+ myeloid cells as well as increased CD11b+cKIT+ cells (Figure 3, A and B). This evidence concerns the gene ITGAM and acute myeloid leukemia.