In comparison to Vav-cre Tp53fl/fl GMPs, tumor suppressor/p21 stabilizer, Rbms2, was downregulated, while transcripts of stem cell genes, Cd34 and Cd44; leukemia enhancer genes, Runx1, Ikzf2, and Gata2; inflammasome gene, Nlrp1b; and Tnfaip3, Pvr (Cd155), and Traf2, were significantly upregulated in GMPs from Vav-cre Tet2fl/flTp53fl/fl mice (Figure 7B and Supplemental Table 4). The gene discussed is VAV1; the disease is leukemia.