Splenocytes of Vav-cre Tet2fl/flTp53fl/fl mice that developed AML had substantially increased frequencies of Cd11b+Gr-1– and Cd11b+Gr-1+ myeloid cells as well as increased CD11b+cKIT+ cells (Figure 3, A and B). The gene discussed is KIT; the disease is acute myeloid leukemia.