IFNA1 and hepatocellular carcinoma: To see if this was the case in PHHs and hepatoma cell lines, we treated Huh7, HepG2-hNTCP C4 and PHHs with 1,000 U ml−1 of IFN-α and 100 ng ml−1 of IFN-λ, which are known to also inhibit HBV replication.