Of the 250 749 patients with ovarian cancer diagnosed between 2004 and 2020 (median [IQR] age, 62.0 [52.0-73.0] years; 0.4% of American Indian, 3.7% Asian, 8.6% Black, 85.2% White, and 2.0% other or unknown race and 6.7% of Hispanic, 88.8% non-Hispanic, and 4.6% unknown ethnicity) (Table 1), 212 477 (84.7%) had CA-125 levels measured at diagnosis. This evidence concerns the gene MUC16 and ovarian carcinoma.