American Indian patients were less likely to have an elevated CA-125 level for all ovarian cancer histologies (AOR, 0.73; 95% CI, 0.57-0.92), and Asian patients were more likely to have an elevated CA-125 level for high-grade serous ovarian cancer (AOR, 1.30; 95% CI, 1.07-1.59). Here, MUC16 is linked to ovarian cancer.