Studies of ovarian cancer screening using CA-125 levels could be reanalyzed to see whether a lower CA-125 threshold might improve sensitivity and stage shift as seen in the UK Collaborative Trial of Ovarian Cancer Screening.28 A 9-day difference in time to chemotherapy initiation for patients with false-negative CA-125 findings may keep some patients within the 42-day recommended window between surgery and chemotherapy start but has the potential to represent a clinically meaningful delay.38 This evidence concerns the gene MUC16 and ovarian carcinoma.