In addition to autoAbs neutralizing IFNα subtypes, autoAbs that neutralize IFNω are also associated with increased susceptibility to developing severe viral disease (Arrestier et al., 2022; Bastard et al., 2020; Gervais et al., 2023; Hale, 2023; Zhang et al., 2022b). The gene discussed is IFNA1; the disease is viral infectious disease.