HKDC1 and cancer: We then generated HKDC1‐deficient human (Caco‐2) and murine (CMT‐93) colonic epithelial cell lines using CRISPR/Cas9 technology, and intestinal organoids, to investigate the role of HKDC1 in proliferation and cell death susceptibility in vitro, since uncontrolled cell division and resistance to cell death are hallmarks of cancer cells.