Studies report dynamic cytokine profiles along the DS‐AD spectrum, resembling an early and a late neuroinflammatory period, with early peaks of upregulated pro‐inflammatory markers like interleukin (IL)‐6, IL‐1β, IL‐15, and macrophage‐derived chemokine (MDC) around age 20.26 This evidence concerns the gene IL15 and Alzheimer disease.