Besides tumor cells, loss of PTEN gene expression has been reported in the stroma of breast (Kurose et al., 2002; Trimboli et al., 2009), prostate (Ashida et al., 2012) and pancreatic cancers (Pitarresi et al., 2018), and is associated with worse outcome in the patients. The gene discussed is PTEN; the disease is familial pancreatic carcinoma.