Accordingly, high expression of ASPH can activate the four pathways of FN1 signaling pathway, COLLAGEN signaling pathway, VISFATIN signaling pathway and SPP1 signaling pathway, these pathways occur mainly in the epithelial, myeloid cell, myeloid cell and macrophage of gallbladder carcinoma. The gene discussed is NAMPT; the disease is gallbladder carcinoma.