Based on literature corroborating the interaction between coronaviruses and polypyrimidine tract binding proteins, namely PTBP1,25, 26, 27, 28 we aimed to validate whether modulation of PTBP1 expression in human blood cells could influence the generation of chimeric RNA transcripts, particularly those found from our analysis of COVID-19 patient whole blood. Here, PTBP1 is linked to COVID-19.