To summarize, the genes showing increased mutation burden, copy number variations, or hypomethylation that we have identified in ICE syndrome patients are primarily associated with pathogenic genes related to ocular diseases (e.g., RP1L1, CYP4F12, and KIR2DL1), viral immunity (e.g., ZNF717 and KIR2DL1), and epithelioid hyperplasia (e.g., MAL). This evidence concerns the gene CYP4F12 and iridocorneal endothelial syndrome.