Gene KIR2DL1 (killer cell immunoglobulin-like receptor, two Ig domains and long cytoplasmic tail 1) located on chr19: 55276166-55295820 (hg19) was reported to be associated with Behcet syndrome and viral infection.48, 49, 50 This indicated that copy number loss of gene ZNF717 and KIR2DL1 may lead to viral infection-induced pathological conversion of corneal endothelial cells in ICE syndrome. The gene discussed is ZNF717; the disease is iridocorneal endothelial syndrome.