When performing gene-based burden testing of rare coding-altering mutations (max gnomAD allele frequency ≤0.01) between the ICE syndrome cohort and normal control on the dominant model, gene RP1L1 (retinitis pigmentosa 1-like 1) was found to have a higher mutation burden in the ICE cohort (27/51) than in gnomAD (735/9197, P = 1.67 × 10−13) (Fig. 1A and Table S3) and our in-house normal Chinese cohort (62/350, P = 2.06 × 10−7) (Table S3). The gene discussed is RP1L1; the disease is iridocorneal endothelial syndrome.