IL6 and major depressive disorder: Although the relationship between DII and depression has been investigated inadults, research examining this relationship in adolescents is limited.Akbaraly et al. [14] reported that high DII scores (indicating apro-inflammatory diet) were positively associated with greater circulating levelsof IL-6 and CRP, as well as a higher risk of recurrent depressive symptoms inadult women of the Whitehall II study.