For instance, the effects ofbrain-derived neurotrophic factor (BDNF) and tyrosine receptor kinase B (TrkB)signaling in the PD model were demonstrated to be an important site for dPAGactivation, as BDNF panicolytic-like effects occur via γ-aminobutyricacid type A (GABAA)-dependent mechanisms. Here, BDNF is linked to Parkinson disease.