AKT1 and Miyoshi myopathy: For example, silymarin has been found to induce apoptosis in MM cells through the PI3K/Akt/mTOR signaling pathway (88), and AE - 848, a novel small molecule compound, effectively induces apoptosis in human MM cells by regulating NF - κB and PI3K/Akt/mTOR signaling pathways (89).CPT1 inhibitors act by blocking fatty acid oxidation through inhibiting CPT1.