NOTUM and gastric cancer: Gao found that GCSCs stemness characteristics were significantly reduced after silencing or down-regulating Stearoyl-CoA-desaturase-1, which may be related to the fact that Stearoyl-CoA-desaturase-1 can activate the Hippo/YAP pathway and enhance the stemness of GCSCs (35), and studies have shown that high expression of Notum enhances gastric cancer cell stemness and up - regulates Sox2 expression via the PI3K/AKT pathway, thereby enhancing tumorigenicity of gastric cancer (36).