ACACA and Disorder of lipid metabolism: Given the pivotal roles that lipid metabolism disorders play in numerous biological processes, including cell proliferation, apoptosis, and inflammation (Blumberg et al., 1995), we performed LC-MS-based lipidomic analysis of the lipid profile of liver samples and detected 43 lipids classes, which include PC, PE, TG, DG, AcCA, FA, and Cer, etc (Figures 4A, B).