NFE2L2 and brain injury: Similarly, Nrf2 activation alleviates apoptosis in doxorubicin-induced cardiomyopathy (Zhang W. et al., 2023)and suppresses astrocyte necroptosis induced by traumatic brain injury (Zhao et al., 2022), and the inhibition of Nrf2 limits the alleviation of pyroptosis in gallic acid-induced gouty arthritis cells (Lin et al., 2020).