CASP1 and acute kidney injury: Similarly, AME inhibited the expression of GSDMD, ASC, and Caspase-1, which mediate pyroptosis, and RIP3 and MLKL, which mediate necroptosis, suggesting that AME can relieve CI-AKI by inhibiting apoptosis, pyroptosis, and necroptosis, i.e., PANoptosis (Zhu et al., 2023).