SIRT1 and pulmonary fibrosis: For example, inhibition of the miR-34a-mediated SIRT1/mTOR signaling pathway attenuates D-gal-induced senescence in rat brain tissue, and alveolar epithelial cell dysfunction is alleviated in aged miR-34a−/− pulmonary fibrosis mice (Kou et al., 2016; Cui et al., 2017).