Moreover, the results of KEGG enrichment analysis demonstrated that these targets are enriched in 164 pathways, of which 153 pathways are statistically significant, mainly involving pathways in cancer, prostate cancer, proteoglycans in cancer, endocrine resistance, human cytomegalovirus infection, lipid and atherosclerosis, Chagas disease, hepatitis B, chemical carcinogenesis - receptor activation, and hypoxia-inducible factor-1 (HIF-1) signaling pathway. The gene discussed is HIF1A; the disease is hepatitis B virus infection.