Via regulating the expression of rno-miR-9a-5p and its downstream target, Nfkb1, rutin suppresses the recruitment of neutrophils into the alveolar spaces, inhibits the induction of early-response cytokines and chemokines, and consequently, the alterations in the following inflammatory cascade events, relieving eventually BLM-induced ALI. Here, NFKB1 is linked to acute respiratory distress syndrome.