MAPK1 and neoplasm: Wang et al. (2015) reported that Curcumol (0.05, 0.1, 0.2, 0.4 μM/mL for 24, 48, 72, 96, 120 h) time- and dose-dependently decreased the protein level of IGF-1R, and upregulated the expression of phosphorylated p38, inducing apoptosis in LoVo cells. In vivo experiments demonstrated that curcuminol inhibited tumor development.