Lyu et al. (2019) reported that Rh1 (0, 50,100 μM) was able to suppress the migration and invasion of SW620 cells by decreasing the ratios of p-P38/P38, p-ERK1/2/ERK1-2 and p-JNK/JNK, downregulating the mRNA expression of MMP1 and MMP3, and upregulating the mRNA expression of TIMP3. The ratios of p-38/p38, p-JNK/JNK, p-ERK/ERK were 0.3, 0.2, and 0.6 respectively. In vitro experiments demonstrated that oral administration of Rh1 (20 mg/kg) significantly reduced CRC tumor weight. Here, MAPK3 is linked to colorectal carcinoma.