Although CTLA-4 (+49 A/G) is associated with IgE levels in Asian females (Yang et al., 2004; Chang et al., 2004; Roshanizadeh et al., 2021), no significant association has been shown between this polymorphism and asthma severity (Roshanizadeh et al., 2021; Lee et al., 2002). The gene discussed is IGHE; the disease is asthma.