It is further confirmed that the expression of lncRNA-NEAT1 and PKM2 is positively correlated, and there is colocalization between lncRNA-NEAT1 and FOXP3, and lncRNA-NEAT1 promotes the proliferation and metastasis of hepatocellular carcinoma by regulating the FOXP3/PKM2 axis. The gene discussed is PKM; the disease is hepatocellular carcinoma.