The results showed that the expression level of lncRNA-NEAT1 in M2 macrophages was significantly increased in tumor tissues, and the expression level of lncRNA-NEAT1 in M2 macrophages was significantly increased, while that in M1 macrophages was significantly decreased, which further suggested that lncRNA-NEAT1 took part in the regulation of M1 and M2 polarization of giant cells. Here, NEAT1 is linked to neoplasm.