In a study (Chen et al., 2023) of lncRNA-NEAT1 and HCC cell senescence, lncRNA-NEAT1 is highly expressed in tumor tissues and hepatocellular carcinoma cells, while the expression of CDKN2A, a biomarker of aging encoding p16INK4a and p14ARF proteins, is decreased, demonstrating a negative correlation. This evidence concerns the gene CDKN2A and neoplasm.