The study also found that BLIMP1 has a significant impact on the miR-377-3p-E2F3 pathway, and discovered that the correlation between lncRNA-NEAT1 and BLIMP1 (B Lymphocyte-Induced Maturation Protein 1) affects the function of immune cells, thereby influencing the immune escape and progression of NSCLC tumor cells, and further participating in the regulation of the tumor immune environment. This evidence concerns the gene E2F3 and non-small cell lung carcinoma.