By analyzing DisGeNET-curated genes (184 for high myopia, 39 for degenerative myopia), our study achieves two advances: (Ohno-Matsui et al., 2016): identifying 21 novel degenerative myopia-associated genes (e.g., THBS1, implicated in collagen degradation and retinal integrity) and 133 high-confidence high myopia-associated genes (e.g., ADCY4, modulating cAMP signaling in axial growth); (Foster and Jiang, 2014); validating the functional relevance of predicted genes through pathway analysis. Here, THBS1 is linked to pathological myopia.