Glioma RNA sequencing data and clinical information were downloaded from TCGA and CGGA databases, and Kaplan-plotter survival analysis and Multivariable COX regression analysis were performed to plot ROC survival curves at 1, 3 and 5 years cBioPortal and MethSurv were used to carefully examine the prognostic value of KIF18B methylation. The gene discussed is KIF18B; the disease is glioma.