Figure 4A shows the ridge plot of GSEA results, highlighting pathways such as the cell cycle, proteasome, DNA replication, and IL-17 signaling. Downregulated genes were enriched in circadian rhythm, drug metabolism-cytochrome P450, phenylalanine metabolism, and taurine and hypotaurine metabolism (Figure 4B). In contrast, upregulated genes were associated with amino acid biosynthesis, cell cycle, proteasome, primary immunodeficiency, and DNA replication (Figure 4C). The gene discussed is IL17A; the disease is inborn error of immunity.