CDCA8 and hepatocellular carcinoma: Yang et al. performed bioinformatics analysis of HCC-related data in TCGA and GEO based on the above two datasets, and found 4 macrophage-related genes (CDCA8, CBX2, UCK2, and SOCS2) with good prognostic independence in HCC, which are expected to be the potential prognostic target [29].