CTNNBIP1 and acute promyelocytic leukemia: In our previous studies examining the role of ICAT in AML differentiation, we found that the entry of β-catenin protein into the nucleus was inhibited by upregulating ICAT expression, and then inhibition of the Wnt/β-catenin signaling pathway induced the differentiation of HL-60 acute promyelocytic leukemia cells into a mononuclear line [20].