Zhao et al. [42] found that Treg markers, such as FOXP3, CCR8, and signal transducer and activator of transcription (STAT)5B were positively correlated with the expression level of Zeb1, suggesting that circUBAP2 can influence the EMT of pancreatic cancer cells through the regulation of miR-494 and target Zeb1 to affect the activity of Tregs for cancer progression. The gene discussed is ZEB1; the disease is cancer.