As a major member of the NKG2D ligand family, ULBP1 plays an important role in NK cell-mediated immune response, which is expressed at a substantially lower level in the mesenchymal phenotype circulating cancer cells than that in the epithelial phenotype, suggesting that circARSP91 may be involved in EMT by altering cytotoxicity of NK cells on hepatocellular carcinoma cells [150]. The gene discussed is ULBP1; the disease is hepatocellular carcinoma.