Zhu et al. [45] revealed that circLONP2, highly expressed in the esophagus, can upregulate the expression level of Zeb1 through miR-27b-3p sponging, as well as affect EMT-related proteins to promote the proliferation, migration, and EMT of ESCC cells. Here, ZEB1 is linked to esophageal squamous cell carcinoma.