Wong et al. [30] demonstrated that the overexpression of circRTN4 in pancreatic ductal adenocarcinoma regulates miR-497-5p to promote oncogenic lncRNA HOTTIP expression, blocks ubiquitination of EMT driver RAB11FIP1, inhibits cellular RAB11FIP1 degradation, and ultimately promotes EMT, cancer growth, and liver metastasis by altering the levels of TFs, such as Slug. The gene discussed is SNAI2; the disease is cancer.