TJP1 and familial pancreatic carcinoma: Li et al. [121] found that circ-IARS, which was substantially upregulated in plasma exosomes from pancreatic cancer tissues and patients with metastatic cancer, not only enhances endothelial single-molecule cell permeability and promotes cancer cell invasion and metastasis, but also directly binds to miR-122, promoting pancreatic cancer cell EMT by inhibiting downstream ZO-1 expression.