Silencing circ_67835 promotes E-cadherin expression to inhibit the occurrence of EMT, suggesting that circ_67835 could be involved in the EMT of HCC through the miR-1236-3p/Twist2 axis to promote cancer cell proliferation and metastasis, which provides a new explanation for circRNAs-mediated EMT regulation through Twist related markers [36]. The gene discussed is TWIST2; the disease is hepatocellular carcinoma.