MiR-217 also proved to be a molecular sponge for circRNA_100367 and can target Snail to reduce E-cadherin expression in radiation-resistant ESCC cells with high EMT ability, suggesting that circ-ZDHHC5 has the potential to regulate Zeb1 in the EMT process in ESCC cells [47]. The gene discussed is ZEB1; the disease is esophageal squamous cell carcinoma.