Mammalian target of rapamycin (mTOR) signaling can also be activated in cancer cells and alters the expression activity of some key metabolic enzymes to regulate cancer metabolism, including ribosome biosynthesis and protein, nucleotide, fatty acid, and lipid synthesis, while mTOR signaling is involved in tumor EMT (Fig. 5C) [169,170]. The gene discussed is MTOR; the disease is cancer.