Immunological reactions and autoimmune diseases may be connected to molecular mimicry secondary to the cross-reactivity of the spike protein of SARS-CoV-2 with human tissue due to viral-antigenic mimicry and bystander activation, which is characterized by the autoreactive stimulation of immune cells, mainly CD8+ T cells, following antigen-specific responses against the viral-specific antigens. The gene discussed is CD8A; the disease is autoimmune disease.