Side effects of TNF-α inhibitors: TNF-α inhibitors are generally well tolerated, but side effects are possible and may include infusion and injection site reactions, minor infections such as upper respiratory tract infections, lupus-like syndrome, hepatitis B virus (HBV) reactivation, liver function test abnormalities, or hepatotoxicity, particularly with infliximab use. The gene discussed is TNF; the disease is Recurrent upper respiratory tract infections.