APP and Alzheimer disease: The administration of Rhy and HA@Rhy@Hf-MOF notably restored the impaired learning and memory capabilities of APP/PS1 transgenic mice, as evidenced by discrimination values that significantly exceeded those of the AD group (P < 0.01, P < 0.001, Figure 3f), where the efficacy of HA@Rhy@Hf-MOF was superior to free Rhy.