Additionally, ovarian cancer-secreted exosomes regulate the p53-β-catenin-CCL2 signaling pathway to induce CCL2 production, which recruits macrophages to the peritoneum and promotes their polarization from the M1 phenotype to the M2 phenotype, thereby facilitating PMN-mediated immune suppression (10). This evidence concerns the gene CCL2 and ovarian carcinoma.