Since aberrant activation of the Wnt/β-catenin signaling confers ferroptosis resistance15 and NRF2 controls iron homeostasis and ferroptosis through HERC2 and VAMP8,16 this gives us a hint that WTX, as their upstream regulatory molecule, may exhibit tumor-suppressor activity by modulating ferroptosis. The gene discussed is AMER1; the disease is neoplasm.