TP53 and acute liver failure: In human acute liver failure tissue, SIRT1 levels are diminished, however, its activation can mitigate cell damage by modulating the ferroptosis and pyroptosis processes in hepatocytes through the regulation of the p53/GPX4/GSDMD and Nrf2/p53 signaling pathway, thereby exerting a protective effect on the liver (Zhou et al., 2024a).