Consequently, the SIRT1/Nrf2 signaling axis emerges as a critical pathway in maintaining chondrocyte integrity and attenuating the degenerative processes in the joint, offering a potential therapeutic strategy for managing osteoarthritis (Zhan et al., 2023; Zhang et al., 2024c; Sun et al., 2023; Ruan et al., 2023). This evidence concerns the gene NFE2L2 and osteoarthritis.