SIRT1 and heart failure: Natural compounds such as resveratrol and pterostilbene have shown inhibition of ferroptosis in cardiomyocytes via the SIRT1/p53 and SIRT1/Glycogen Synthase Kinase-3β (GSK-3β)/GPX4 signaling pathways, improving cardiac function and reducing cardiac remodeling in heart failure models (Zhang et al., 2023b; Zhang et al., 2024b).