In melanoma studies, ubiquitin specific peptidase 22 controls melanoma metastasis and sensitivity to ferroptosis through the SIRT1/phosphatase and tensin homolog deleted on chromosome 10 (PTEN)/phosphoinositol-3 kinase (PI3K) signaling pathway, suggesting that activation of the SIRT1 pathway may enhance melanoma cells’ sensitivity to ferroptosis (Sun et al., 2024). This evidence concerns the gene SIRT1 and melanoma.