SIRT1 activators such as resveratrol, SRT1720, and SRT2104 have been shown to alleviate neurodegenerative disease symptoms by reducing oxidative stress, enhancing autophagy flux, and promoting neuronal survival (Su et al., 2021; Zhu et al., 2022; Bai et al., 2023; Rao et al., 2024). Here, SIRT1 is linked to neurodegenerative disease.