Using these models, we tested a number of clinically available and novel therapeutics for preeclampsia including aspirin, metformin, resveratrol and FKBPL-based therapeutic peptide mimetic, AD-01 (Cluver et al., 2019; Bujold et al., 2010; Caldeira-Dias et al., 2019; Ghorbanpour et al., 2024). The gene discussed is FKBPL; the disease is preeclampsia.