IL6 and diabetes mellitus: Another study indicated that STZ-induced diabetes exacerbated RGCs functional impairment and loss in the glaucoma DBA/2 J mouse model, accompanied by increased glial reactivity and elevated expression of oxidative stress markers, IL-6 and TNF-α, showing that diabetes can promote oxidative stress and inflammation-mediated RGCs' functional impairment and glial reactivity [28].