In the case of leprosy, we believe that the mediators CXCL8, CCL3, CXCL10, IL-9, IL-6, and IFN-γ could be considered as potential biomarkers for the future development of rapid assays that could assist in the diagnosis and prognosis of leprosy and leprosy reactions. This evidence concerns the gene CXCL10 and leprosy.