The analysis of the leprosy reaction patients demonstrated that while CCL3, CXCL10, CXCL8, CCL4, and IL-1Ra (5/27, 19%) presented higher significance (p < 0.01) for T1LR, a large set of attributes (12/27, 44%) were selected for T2LR, which included IFN-γ, CCL3, CXCL8, CXCL10, CCL4, G-CSF, IL-1Ra, IL-6, TNF-α, IL-17, IL-9, and IL-15 (Figure 2). This evidence concerns the gene TNF and leprosy.