However, existing studies suggest that the gut microbiota may influence tumorigenesis and progression through various mechanisms, which may also be applicable to renal cancer.For example, in a Min mouse model, the pathogenic pks-positive Escherichia coli strain (11G5) was found to significantly induce tumorigenesis while increasing both the size and number of adenocarcinomas (5). The gene discussed is ARAF; the disease is adenocarcinoma.