1. Reduces immunosuppressive cytokine levels and induces tumor-specific antigen presentation.2. Regulates hypoxic TME, alleviates hypoxia-related immunosuppression and enhances the antitumor immune response.3. Enhances mitochondria-associated iron death, increases phagocytosis by dendritic cells and macrophages and induces cross-presentation of antigens.4. Accumulates in tumor cells and initiates CD8+ T-cell infiltration into the TME.5. Induces immunogenic tumor cell death and retards tryptophan metabolism. Here, CD8A is linked to neoplasm.