DPP6, a key modulator of Kv4 channels, is predominantly expressed in the brain, underscoring its critical role in regulating these ion channels and contributing significantly to processes such as chronic pain modulation and synaptic integration, which are closely associated with a range of neurological disorders (Birnbaum et al., 2004; Hu et al., 2006; Cai et al., 2004). The gene discussed is DPP6; the disease is nervous system disorder.