In the 3D organoids, there were noticeable deposits of trichrome stain, Collagen 3A1 (COL3A1), periostin, as they are ECM markers that have been explored in UF, ‐catenin, since it is involved in UF pathogenesis and Oestrogen Receptors (ERα) as this isa hormonal dependent tumour. Here, COL3A1 is linked to neoplasm.