Vasoactive substances like leptin, adiponectin, tumour necrosis factor-alpha (TNF-), interleukin-1 (IL-1), interleukin-6 (IL-6), and other inflammation-related adipokines, PAI-1, angiotensinogen, and endothelin, as well as molecules that may contribute to insulin resistance like FFA, TNF- and resistin, are among them which participate in the inflammation process and affect metabolic function and might play a role in causing cardiovascular end-organ damage. Here, TNF is linked to Insulin resistance.