DSP and hereditary palmoplantar keratoderma: Naxos disease variant (Carvajal syndrome) is a cardiocutaneous genetic disease caused by Plakoglobin and Desmoplakin gene mutation, and usually manifests with woolly hair, palmoplantar keratoderma, and cardiomyopathy, and are found to have a high risk for uncontrolled arrhythmia.