IFN-γ can potentiate immunosuppression via the upregulation of nerve growth factor receptor (NGFR)/CD271 and the downregulation of melanoma antigen recognized by T-cell-1 (MART-1) and premelanosome protein (PMEL/gp100) [145], thereby promoting the MITFlow/NGFRhigh neural crest stem-like dedifferentiation phenotype of melanoma cells. The gene discussed is NGFR; the disease is melanoma.