In addition, the inhibition of mouse double minute 2 (MDM2) followed by p53 activation was associated with the upregulation of genes related to IFN-γ signaling, including MHCII, in melanoma [120], which is consistent with the previously reported contribution of p53 to IFN-γ-dependent PD-L1 regulation [121]. Here, TP53 is linked to melanoma.