In addition, Treg cells repress IFN-γ derived from CD8 + T-cells to sustain TAMs by promoting sterol regulatory element binding transcription factor 1 (SREBP1)-dependent lipid metabolism, while inhibition of the SREBP1 pathway cooperates with anti-PD-1 therapy to reduce melanoma tumor growth [132]. This evidence concerns the gene SREBF1 and neoplasm.