AKT1 and melanoma: IFN-γ promotes ultraviolet-mediated melanomagenesis [15] and melanoma cell survival by regulating CD74-macrophage-migration inhibitory factor (MIF) signaling, leading to the activation of AKT phosphorylation and the expression of IL-6, IL-8, and B-cell leukemia/lymphoma-2 (BCL-2) [16].