In this respect, antagonists of the Toll-like receptors TLR2 and TLR6 synergistically with IFN-γ increase the expression of C-X-C motif chemokine ligand 10 (CXCL10), CXCL11, IL-8, IL-32, and cathepsin S in melanoma cells [70]. The gene discussed is CXCL8; the disease is melanoma.