In turn, IFN-γ induces cell cycle arrest in melanoma cells via the upregulation of JAK/STAT/miR-29 signaling, which is followed by the inhibition of cyclin-dependent kinase 6 (CDK6) [10], the accumulation of the cyclin-dependent kinase inhibitor p27 and the downregulation of S-phase kinase-associated protein 2 (SKP2) [11]. Here, SKP2 is linked to melanoma.