IFNG and neoplasm: Interestingly, the secretion of IFN-γ is significantly lower in B2M-knockout melanoma cells cocultured with matched tumor-infiltrating lymphocytes than in control cells [131], although B2M-knockout melanoma cells respond to IFN-γ via the upregulation of typical IFN-γ-dependent genes, but are not recognized by antigen-specific T-cells due to a lack of surface MHC-I proteins [125].