Our findings that Sst-expressing ALS cells are mainly located in the lateral reticulated part of lamina V27, and that their main target within LPB is the internal lateral (PBil) nucleus, are consistent with anterograde tracing studies in the rat, which showed that PBil is innervated by spinal projection neurons located in deep grey matter, including cells in the lateral lamina V, but not by neurons in superficial laminae6,7. Here, SST is linked to amyotrophic lateral sclerosis.