ELANE and neoplasm: Interestingly, immunosuppressive impacts of the mature neutrophils from humans are currently demonstrated as follows: i) a suppression of T-cell proliferation in an integrin Mac-1- and ROS-dependent manner23, ii) an interference of T helper 1 responses from serine proteases and neutrophil elastase through the cleavage of monocyte CD14 and several co-stimulatory molecules of dendritic cells24, and iii) the tumor-associated neutrophils in cancers25.