With the t-Distributed Stochastic Neighbor Embedding (tSNE) visualization of PBMC staining in sepsis, the figures demonstrated that LDN (CD66b-positive cells in the PBMC fraction) are a strong expression of surface PD-L1 population, while PD1-positive cells were CD3 + T cells (Fig. 4E). This evidence concerns the gene CD274 and Sepsis.