In comparison with the normal density neutrophils (NDN) from the same patients (NDN-sepsis) or healthy control (NDN-HC), LDN from sepsis (LDN-sepsis) exhibited higher expression of the degranulation markers, including CD66b (specific granule marker) and CD63 (primary granule marker), CD11b (integrin alpha M), and CD184 (Fusin or CXCR4), with lower expression of CD62L (L-selectin) and CD182 (chemotaxis-associated CXCR2), which obviously differed from other groups (Fig. 1D,E). This evidence concerns the gene CXCR4 and Sepsis.