Intrinsic RS can be boosted to drive strong cytotoxic responses in Myc-driven cancer cells, opening up an avenue for targeted intervention based on the exacerbation of the DNA damage response (DDR), as shown by targeting the ATR/CHK1 pathway, RAD21, BRCA1, TOP1 [10–13], and more recently CDK12 [14]. This evidence concerns the gene MYC and cancer.