IFN-γ plays a critical role as an inflammatory cytokine, inciting dysfunction in salivary gland epithelial cells, and its levels are prominently elevated in the salivary glands of SS patients.15,16 To emulate the inflammatory milieu characteristic of SS, the rat SMG epithelial polarized cell line, SMG-C6, was exposed to IFN-γ. This evidence concerns the gene IFNG and synovial sarcoma.