As summarized in a recent review, several TLRs, including TLR2, TLR3, TLR4, TLR7, and TLR9, are involved in the pathogenesis of SS by modulating inflammatory factor expression, B cell maturation, and salivary epithelial cell apoptosis.28 Accordingly, we performed qPCR to detect the changes of these above mentioned TLRs in the SMGs of BALB/c and NOD mice. This evidence concerns the gene TLR3 and synovial sarcoma.