This finding elucidates why various large molecules, such as β2-microglobulin, lactoferrin, soluble sialic acid-binding immunoglobulin-like lectin-5, cytokines (e.g., IL-17, IL-6, IL-10, and TNF-α), antibodies against muscarinic acetylcholine receptor M3, calprotectin, C-reactive protein, and albumin, are elevated in the saliva of SS patients relative to healthy individuals.34–38 The potential use of these salivary biomarkers as non-invasive diagnostic indicators for SS may derive from the absence of tricellulin in epithelial cells. This evidence concerns the gene MARVELD2 and synovial sarcoma.