SNCA mRNA were found significantly more expressed in oligodendrocyte progenitor-like (OPC-like) subgroup compared with astrocyte-like (AC-like), neural progenitor like (NPC-like) and mesenchymal-like (MES-like) subgroups (P < 0.001) within malignant GBM cells (Fig. 1B, right panels), and while detected in macrophages, higher levels of SNCA were detected in normal oligodendrocytes than in malignant cells, macrophages and T-cells (Fig. 1C, P < 0.001). Here, SNCA is linked to glioblastoma.