Among these 15 DEGs were 7 IFN-response genes (TMEM140, HERC6, OASL, IFI44, RSAD2, PLAC8, and SLFN12L [SLFN5]) indicating stronger responsiveness of the CXCR3+ B cell subset to IFN signaling in MS (Figures 6G and S5H). This evidence concerns the gene HERC6 and myeloid sarcoma.