BTECs start their interactions, and B cells are probably most important for initiating, amplifying, and sustaining the inflammatory response, the antigen presentation, and attraction to the CNS compartment, while T cell-derived IFN-γ enhances HLA-class II expression, immune synapse formation, AP, and the recognition of MS autoantigens, which may all contribute to inflammation in the brain. This evidence concerns the gene IFNG and myeloid sarcoma.