The abundance of IgM in AP+ CXCR3+ B cells is interesting since lipid-reactive oligoclonal IgM antibodies have been linked with cognitive decline74 and increased brain atrophy75 and to indicate a worse disease evolution in MS,76 and AP+ CXCR3+ B cells may be involved in this process. This evidence concerns the gene CXCR3 and myeloid sarcoma.