IL6 and Sepsis: We found that MG exposure in HUVECs induces interleukins typical of the early phase of sepsis (e.g. interleukin-6, 8, and 1β, as well as soluble TNF receptor I and II, at the time of TER loss [Fig. 1f]), as they are pro-inflammatory and activate the innate immune response (Fig. 2g, first column; SI Figure S3, first column).26